The U.S. equity markets experienced varied movements on Tuesday, highlighted by a notable decline in the Dow Jones Industrial Average by approximately 250 points. Despite this broader market downturn, several high-profile stocks recorded meaningful advances during the trading session.
Leading the gains was Moderna Inc (NASDAQ:MRNA), which surged 12.8% to $38.20 following its presentation at the 44th Annual J.P. Morgan Healthcare Conference. The biotechnology company provided an optimistic financial outlook, raising its expected revenue for 2025 to roughly $1.9 billion. This figure surpasses the midpoint of its earlier guidance shared during the third-quarter earnings call by $100 million. Additionally, Moderna announced improved anticipated 2025 GAAP operating expenses, trimming them by $200 million, and projected an increased year-end cash balance of about $8.1 billion. These financial updates appear to have bolstered investor confidence in the company's trajectory.
Other notable risers included TryHard Holdings Ltd (NASDAQ:THH), which soared 69.3% to $39.11. The company's stock benefited from news of a binding collaboration agreement with Carnegie Hill Capital Partners to form a Hong Kong-based investment fund, alongside the initiation of a $10 million share repurchase program.
Semiconductor firm TTM Technologies Inc (NASDAQ:TTMI) experienced a 20.2% gain, pushing its shares to $93.59, while Wheels Up Experience Inc (NYSE:UP) climbed 19.2% to $1.19.
In the energy sector, Kosmos Energy Ltd (NYSE:KOS) increased 16.4% to $1.20 after announcing a $350 million Nordic bond offering, signaling aggressive funding strategies. T1 Energy Inc (NYSE:TE) followed with a 15.2% rise to $8.32.
Biotechnology stocks Structure Therapeutics Inc (NASDAQ:GPCR) and Contineum Therapeutics Inc (NASDAQ:CTNM) each rose by 15%, with their shares closing at $79.75 and $10.55, respectively.
Canadian Solar Inc (NASDAQ:CSIQ) reported a 13.5% increase to $22.98 post-closure of its $230 million convertible senior notes offering due in 2031, supporting its capital structure and growth initiatives.
Posco Holdings Inc (NYSE:PKX) shares rose 12.5% to $60.55, continuing their upward trend.
In retail and technology, Warby Parker Inc (NYSE:WRBY) advanced 10.5% to $29.36, spurred by reports that Meta is considering doubling production of Ray-Ban smart glasses, potentially lifting demand for the eyewear company.
Option Care Health Inc (NASDAQ:OPCH) shares climbed 10.2% to $35.33 after releasing preliminary fourth quarter and full-year 2025 financial results, attracting investor interest.
Kennametal Inc (NYSE:KMT) gained 8.4% to $33.32 following a Jefferies analyst upgrade from Hold to Buy, accompanied by an increased price target, signaling improved analyst sentiment towards the company's prospects.
Intel Corp (NASDAQ:INTC) saw an 8% rise to $47.56 after KeyBanc shifted its rating from Sector Weight to Overweight, reflecting greater confidence in the semiconductor maker's outlook.
Roblox Corp (NYSE:RBLX) shares rose 8% to $82.93. While maintaining an Overweight rating, Morgan Stanley's analyst lowered the price target from $170 to $155, indicating a cautious optimism about the gaming platform’s future.
Chipmaker Advanced Micro Devices Inc (NASDAQ:AMD) jumped 6.6% to $221.30 after KeyBanc upgraded the stock from Sector Weight to Overweight, signaling increased investor interest.
Overall, Tuesday’s session presented a landscape where select stocks—particularly in healthcare, energy, and technology sectors—demonstrated robust gains amid a broader market setback represented by the Dow Jones decline. Key drivers ranged from positive financial outlooks, new capital initiatives, collaboration agreements, and analyst upgrades, all influencing specific stock performances.