January 21, 2026
Finance

Nasdaq Edges Slightly Down Amid Mixed U.S. Market Activity; Johnson & Johnson Surpasses Q4 Expectations

Mixed Movements in Key Indices with Notable Earnings Surprises and Sector Divergences Mark Midweek Session

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Summary

U.S. stock markets experienced a mixed trading day, with the Nasdaq Composite inching downward while the Dow and S&P 500 posted modest gains. Johnson & Johnson delivered stronger-than-anticipated fourth-quarter earnings and provided optimistic guidance for fiscal 2026. Sector performances varied widely, highlighting energy gains and consumer staples weakness, with several individual stocks showing notable price swings due to earnings and corporate actions.

Key Points

Nasdaq Composite decreased slightly by 0.06% while Dow increased 0.30% and S&P 500 rose 0.16%, reflecting mixed market performance on Wednesday.
Johnson & Johnson outperformed earnings expectations with Q4 adjusted EPS of $2.46 and revenue of $24.56 billion, raising its fiscal 2026 guidance for earnings and sales.
Energy sector shares gained 2%, whereas consumer staples stocks declined 0.5%, illustrating divergent sector trends.
Individual stocks displayed wide price movements with PAVmed up 246% following a VA contract, Progress Software up 22% after strong earnings and guidance, and Lisata Therapeutics up 86% due to an acquisition agreement.

On Wednesday, U.S. equities illustrated a split performance as investors digested quarterly earnings reports and sector-specific developments. The technology-heavy Nasdaq Composite edged down 0.06% closing at 22,940.77, reflecting cautious sentiment in the sector. By contrast, the Dow Jones Industrial Average climbed 0.30%, ending the session at 48,632.75, displaying resilience amid the mixed environment. The broader market benchmark, the S&P 500, rose moderately by 0.16% to 6,807.83, suggesting a balanced trading day shaped by divergent sector trends.

Energy stocks stood out as the top-performing segment, advancing approximately 2% during the session, buoyed by gains in commodity prices and possibly supportive demand forecasts. Conversely, the consumer staples sector saw a decline of 0.5%, indicating some profit taking or cautious outlooks within that traditionally defensive category.

Johnson & Johnson Earnings Exceed Estimates

Among the corporate earnings announcements shaping market dynamics, Johnson & Johnson (NYSE: JNJ) reported full-year fiscal 2023 results that surpassed Wall Street expectations. The healthcare conglomerate recorded adjusted earnings per share of $2.46 for the fourth quarter, marking a significant 20.6% year-over-year increase and exceeding the consensus figure of $2.44. Revenue for the quarter reached $24.56 billion, reflecting a 9.1% increase compared to the prior year and surpassing the anticipated $24.16 billion.

Looking forward, Johnson & Johnson issued guidance for fiscal 2026 adjusted earnings ranging from $11.43 to $11.63 per share, slightly above analysts' consensus of $11.45. The company also forecasted sales between $99.50 billion and $100.5 billion, again outpacing the expected $98.89 billion. These projections suggest confidence in continued growth and operational efficiency going forward.

Stocks With Significant Price Movements

Several individual stocks traded with exceptional volatility. Shares of PAVmed Inc (NASDAQ: PAVM) surged dramatically, shooting up 246% to $21.43. This surge followed an announcement that its subsidiary, Lucid Diagnostics, secured a contract with the U.S. Department of Veterans Affairs for its EsoGuard Esophageal DNA Test, an innovative medical diagnostic tool.

Progress Software Corp (NASDAQ: PRGS) shares followed with a 22% uplift to $47.08. The company reported fourth-quarter adjusted earnings per share surpassing expectations and provided first-quarter earnings guidance above analyst forecasts. It also raised its full-year 2026 outlook beyond consensus, fueling investor optimism.

Lisata Therapeutics Inc (NASDAQ: LSTA) saw its stock ascending 86% to $4.01 after revealing a binding term sheet for acquisition by Kuva Labs at $4.00 per share in an all-cash tender offer, highlighting activity in the biotechnology M&A space.

Declines Weigh on Market Performance

On the downside, Venus Concept Inc (NASDAQ: VERO) shares declined steeply by 55% to $1.99 following the firm’s announcement of its intention to delist from the Nasdaq exchange. Similarly, Innovation Beverage Group Ltd (NASDAQ: IBG) shares dropped 38% closing at $0.96 after disclosing a business update regarding its energy market expansion and a proposed merger with BlockFuel Energy. Gibraltar Industries Inc (NASDAQ: ROCK) also experienced a decline, falling 18% to $44.70 after its preliminary fourth-quarter adjusted earnings per share results fell short of estimates.

Commodity Market and Global Indices Overview

In commodities, crude oil prices eased 0.5%, settling at $60.09 per barrel. Conversely, gold prices gained 2%, reaching $4,862.70 per ounce. Silver prices decreased slightly by 0.6%, landing at $94.110, while copper edged higher by 0.4% to $5.8345 per pound.

Across international markets, European shares presented mixed results: the STOXX 600 index in the eurozone edged up 0.03%, Spain’s IBEX 35 increased 0.19%, London’s FTSE 100 added 0.27%, whereas Germany’s DAX declined 0.47%, and France’s CAC 40 gained 0.14%. In the Asia-Pacific region, markets were similarly split with Japan’s Nikkei down 0.41%, Hong Kong’s Hang Seng rising 0.37%, Shanghai Composite improving 0.08%, and India’s BSE Sensex retreating 0.33%.

U.S. Economic Indicators

U.S. housing market data highlighted mixed signals during the week ending January 16. Mortgage applications rose by 14.1%, following a robust increase of 28.5% in the previous week, signaling heightened homebuying activity. However, pending home sales experienced a 9.3% decrease in December month-over-month after a 3.3% increase in November, and underperforming market expectations of a slight 0.3% decline. Additionally, construction spending in the U.S. grew by 0.5% in October compared to a 0.6% increase in September, also exceeding forecasts of a 0.1% gain.

Outlook and Market Positioning

Market analytics highlight several stocks positioned to potentially outperform in 2026, based on factors such as value, momentum, and quality metrics. Some of these names have demonstrated significant gains already, with one surging over 80% whereas sector peers have lagged behind. These trends invite investor attention as they suggest possible leaders for the upcoming year.

Risks
  • Venus Concept's plan to delist from Nasdaq led to a sharp 55% drop in its share price, injecting uncertainty about its future trading and investor accessibility.
  • Innovation Beverage Group's shares fell 38% amid its announcement of a business update and proposed merger, reflecting potential investor concerns about integration or growth.
  • Gibraltar Industries posted preliminary fourth-quarter earnings below expectations, weighing on share performance and signaling possible operational challenges.
  • The decline in U.S. pending home sales by 9.3% contrasts with rising mortgage applications, suggesting uneven housing market conditions that could impact economic outlooks.
Disclosure
Education only / not financial advice
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Ticker Sentiment
IBG - negative JNJ - positive PAVM - positive PRGS - positive LSTA - positive
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