January 5, 2026
Finance

US Markets Advance With Gains Led by Dow; Select Stock Movements Highlight Trading Day

Dow Jones Climbs Over 250 Points Amid Sector Variability and Biotech FDA Update

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Summary

On Monday, U.S. equity markets experienced gains with the Dow Jones Industrial Average rising more than 250 points. Major indexes including the NASDAQ and S&P 500 also posted positive returns. The energy sector outperformed, increasing by nearly 3%, while consumer staples declined modestly. Notable company-specific swings featured shares of Momentus and TMD Energy surging, while Zenas Biopharma and Lavoro faced steep declines. Concurrently, commodity prices for oil, gold, silver, and copper advanced. European and most Asian markets showed strength, and the forthcoming ISM manufacturing PMI is anticipated by investors.

Key Points

The Dow Jones Industrial Average advanced by more than 250 points, reflecting strengthening U.S. equity markets on Monday morning.
Energy sector led gains with a 2.9% increase, while consumer staples declined slightly by 0.4%.
FDA lifted the clinical hold on GH Research’s investigational drug GH001, removing barriers to ongoing clinical trials.
Individual stocks experienced significant moves; Momentus rose 94% driven by new additive-manufactured fuel tank development, while Zenas Biopharma fell 55% after Phase 3 trial results.

The U.S. equity markets moved higher during the Monday trading session, led by a strong performance in the Dow Jones Industrial Average, which climbed upwards by more than 250 points. At market open, the Dow traded up 0.54%, reaching 48,641.58 points, reflecting the favorable investor sentiment.

Alongside the Dow's gains, the NASDAQ Composite index increased by 0.65%, arriving at 23,386.57, while the S&P 500 also showed improvement, rising 0.63% to 6,901.52. These figures suggest widespread positive momentum across major U.S. indices during the early trading hours.

Within market sectors, energy stocks demonstrated the most substantial advancement by climbing approximately 2.9%, highlighting strength in commodities-related industries. Conversely, consumer staples experienced a decline of around 0.4%, indicating some sector-specific pressure.

A key regulatory development contributed to market dynamics: the U.S. Food and Drug Administration (FDA) lifted the clinical hold on the Investigational New Drug (IND) application for GH Research Plc's experimental treatment GH001. The removal of this hold potentially paves the way for continued clinical trials and may influence investor outlook for the biotech firm.

Among individual equities exhibiting notable trading activity, Momentus Inc led the charge with a remarkable surge in its share price. The company's stock increased by 94% to $11.14 following an announcement regarding the creation of an additive-manufactured fuel tank intended for flight testing on the Vigoride-7 orbital service vehicle. This technological advancement appears to have resonated positively with investors.

TMD Energy Ltd also posted significant gains during Monday's session, with shares rising 76% to $0.78, signifying strong investor interest. Meanwhile, VerifyMe Inc shared an uptick of 40% to $0.94 after entering into a letter of intent for a strategic merger with Open World. This potential merger could present new opportunities for growth and scalability, driving the uptick in stock price.

In contrast, certain companies faced pronounced declines in their share prices. Zenas Biopharma Inc saw a steep drop of 55% to $15.54 subsequent to the announcement of clinical trial results from its Phase 3 INDIGO trial for obexelimab targeting immunoglobulin G4-related disease. The outcome of this trial evidently influenced the market’s assessment of the firm's prospects.

Signing Day Sports Inc also experienced a share price decrease, falling by 37% to $0.60. Similarly, Lavoro Ltd's stock declined by 26% to $0.82, reflecting negative trading pressure during the session.

Turning to the commodities market, price movements were broadly positive during the trading day. Crude oil prices increased by 1.4%, reaching $58.12 per barrel, indicating strengthening demand or supply considerations. Gold posted a gain of 2.4%, trading at $4,433.50, while silver exhibited a particularly notable rise of 7.5%, moving to $76.32. Copper prices also ascended 4.1%, hitting $5.9260, further underscoring commodity market buoyancy.

On the international front, equity markets in the Eurozone registered gains. The STOXX 600 index rose 0.5%, Spain’s IBEX 35 increased by 0.3%, London’s FTSE 100 added 0.4%, Germany’s DAX grew by 0.2%, and France’s CAC 40 advanced 0.1%. This broad-based positive performance captures investor appetite across major European markets.

In the Asia Pacific region, market performance was generally positive with some variability. Japan’s Nikkei 225 led gains with a 2.97% increase, while the Shanghai Composite added 1.38%, and Hong Kong’s Hang Seng Index modestly rose by 0.03%. Conversely, India’s BSE Sensex recorded a slight decline of 0.38%, reflecting nuanced regional dynamics.

Investors are now looking ahead to upcoming economic data, notably the release of the ISM manufacturing Purchasing Managers' Index (PMI) today. This report is closely watched as an indicator of manufacturing sector health and broader economic trends.

Overall, the market's upward movement on Monday was bolstered by positive sector performances, significant company-specific news, and favorable commodity trends. Nevertheless, some stocks faced substantial losses due to clinical trial results and corporate developments. The interplay of these factors reflects a market responsive to both macroeconomic cues and individual corporate news flow.

Risks
  • Phase 3 clinical trial results for Zenas Biopharma’s obexelimab negatively impacted its stock, indicating clinical outcomes pose substantial risk for biotech firms.
  • Shares of Signing Day Sports and Lavoro Ltd declined sharply, highlighting potential business challenges or market sentiment risks.
  • Market volatility remains influenced by ongoing regulatory decisions such as FDA holds or releases impacting drug development timelines.
  • Economic data releases like the ISM manufacturing PMI could induce market fluctuations depending on results versus expectations.
Disclosure
Education only / not financial advice
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