December 31, 2025
Finance

U.S. Markets Retreat Amid Steep Crude Oil Inventory Drop and Varied Pharmaceutical Stock Movements

Dow Jones and Nasdaq Fall While Energy Supplies and Sector Performances Signal Market Caution

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Summary

U.S. equity markets experienced a downturn during midweek trading with major indices slipping modestly. The Dow Jones Industrial Average dropped over 100 points, pressured by sector declines and a notable drawdown in crude oil inventories. Mixed performances were seen across healthcare and tech stocks, with some pharmaceutical firms surging on regulatory news while others faced significant setbacks. Commodity prices showed mild shifts as global markets exhibited uneven activity.

Key Points

Major U.S. stock indices including the Dow Jones, Nasdaq, and S&P 500 declined modestly amid market caution.
U.S. crude oil inventories (excluding the Strategic Petroleum Reserve) fell by 1.934 million barrels, exceeding expectations and marking the largest weekly drawdown since mid-November.
Pharmaceutical companies such as Anghami, Vanda Pharmaceuticals, and Intelligent Bio Solutions recorded significant stock gains linked to positive earnings, FDA approval, and strategic partnerships respectively.
Corcept Therapeutics shares plunged sharply following a negative FDA response letter for its drug; FuelCell Energy and Security Matters also saw notable share price declines.

During Wednesday's trading session, major U.S. stock indices moved lower, reflecting investor apprehension amid declining crude oil inventories and sector-specific developments. The Dow Jones Industrial Average fell approximately 0.28%, closing at 48,229.87 points, a drop of more than 100 points from its previous close. The NASDAQ Composite slipped by 0.26%, ending the day at 23,359.33, while the S&P 500 also retreated by 0.26% to 6,878.07.

Sectoral analysis showed utilities experienced a slight reduction, decreasing by 0.2%, indicating steady but cautious investor sentiment in defensive areas. Real estate equities declined by 0.8%, suggesting some pressure within that market segment amidst broader market softness.

Crude Oil Inventories Decline Significantly

One key factor contributing to the market mood was the notable contraction of U.S. crude oil inventories. Excluding the Strategic Petroleum Reserve, crude stockpiles dropped by 1.934 million barrels during the week ending December 26. This decrease represents the largest weekly decline recorded since mid-November, surpassing market expectations that had anticipated a fall of approximately 0.9 million barrels. This sharper-than-expected drawdown in oil supplies could imply tightened availability, influencing energy market dynamics and investor considerations.

Equities Experiencing Gains

Within individual company performances, notable increases were observed in certain stocks. Anghami Inc. (NASDAQ:ANGH) shares soared by 50%, closing at $3.7306, propelled by the company’s reported year-over-year growth for the first half of its fiscal year. This significant price appreciation signals strong investor enthusiasm following the positive financial results.

Similarly, Vanda Pharmaceuticals Inc. (NASDAQ:VNDA) experienced a robust 32% rise in share price, ending at $9.28. The upswing came after the company received Food and Drug Administration (FDA) approval for NEREUS, a treatment aimed at preventing motion-induced vomiting, marking a critical milestone in the company's product portfolio development and regulatory progress.

Intelligent Bio Solutions Inc. (NASDAQ:INBS) experienced an even more striking increase, with shares surging 102% to reach $8.27. The stock rally followed the announcement of a strategic manufacturing partnership with Syrma Johari MedTech. This alliance is intended to enhance and expand production capabilities for the company’s Intelligent Fingerprinting Drug Screening Reader, indicating a scaling phase to meet anticipated demand.

Stocks Facing Downward Pressure

Conversely, other equities faced considerable losses during the session. Corcept Therapeutics Incorporated (NASDAQ:CORT) shares declined by about 52%, closing at $34.04. This steep drop followed the company's disclosure of receiving a Complete Response Letter from the FDA concerning its drug candidate Relacorilant, signaling regulatory obstacles that could delay or impede the drug’s market progress.

FuelCell Energy, Inc. (NASDAQ:FCEL) shares fell 10% to $7.18 after the company filed for an amended common stock offering, an action which might contribute to investor concerns about dilution or company financing needs. Meanwhile, SMX (Security Matters) Public Limited Company (NASDAQ:SMX) saw its share price decline by 37% to $32.30, reflecting broader market challenges or company-specific issues occurring in the cybersecurity sector.

Commodity Markets and Global Equities

In commodity markets, crude oil prices edged up slightly by 0.1%, reaching $58.02 per barrel, reinforcing the impact of shrinking inventories on pricing. Precious metals experienced declines, with gold decreasing by 0.8% to $4,351.00. Silver exhibited a sharper slide, falling 7.3% to $72.255, while copper also declined by 1.9% to $5.6710.

International equity markets showed mixed activity. European indices recorded minor losses with the eurozone’s STOXX 600 retreating 0.14%, Spain’s IBEX 35 decreasing 0.27%, London’s FTSE 100 dropping 0.09%, and France’s CAC 40 falling 0.23%. These movements reflect cautious investor positioning in key European markets amid uncertain economic conditions.

In the Asia-Pacific region, markets showed a blend of performance metrics. Hong Kong’s Hang Seng Index declined by 0.87%, while China’s Shanghai Composite inched up by 0.09%. India’s BSE Sensex posted gains of 0.64%, illustrating resilient demand and investor confidence in certain emerging market segments.

Employment Data and Market Implications

On the economic front, the U.S. Department of Labor reported that initial jobless claims decreased by 16,000, reaching 199,000 for the week ending December 27. This figure was notably below analyst forecasts that had anticipated claims of 220,000, reflecting ongoing strength in the labor market which could inform monetary policy and consumer spending trends.


Risks
  • Regulatory setbacks exemplified by Corcept Therapeutics' FDA Complete Response Letter may delay product launches and impact stock valuations.
  • A larger-than-expected decline in crude oil inventories could introduce volatility in energy markets affecting related sectors and overall market sentiment.
  • Equity offerings, such as FuelCell Energy's amended stock sale, can raise concerns about shareholder dilution and corporate financing health.
  • Significant decreases in share prices for companies like SMX indicate potential underlying business or sector-specific challenges that may persist.
Disclosure
Education only / not financial advice
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Ticker Sentiment
ANGH - positive VNDA - positive INBS - positive CORT - negative FCEL - negative
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