In early Wednesday trading, futures contracts for major U.S. stock indexes indicated a downward trajectory, with Dow Jones futures losing about 100 points. This broad market softness coincided with notable falls in several companies’ share prices during pre-market hours.
The most pronounced move was observed in Glaukos Corp (NYSE:GKOS), whose shares plummeted 12.1% to $96.97 in pre-market trading following the release of preliminary sales expectations for the fourth quarter and fiscal year 2025. The medical technology company projected fiscal year 2025 sales to reach approximately $507 million. Market participants reacted negatively to this outlook, reflecting in the significant price correction before the opening bell.
Alongside Glaukos, other equities faced substantial headwinds ahead of regular trading. BriaCell Therapeutics Corp (NASDAQ:BCTX) experienced a steep 53.1% drop, settling at $5.12 in pre-market activity after announcing the pricing of a public offering valued at $30 million. The capital raise appears to have influenced investor sentiment unfavorably, leading to the marked decline.
Travel services provider Trip.com Group Ltd (NASDAQ:TCOM) declined 9.3% to $68.55 in pre-market trading. The drop followed confirmation that the Chinese State Administration for Market Regulation (SAMR) has launched an investigation into the firm for potential anti-monopoly violations. This regulatory scrutiny introduces uncertainty around the company’s near-term prospects.
Other companies registering losses before markets opened included Pearson PLC (NYSE:PSO), which fell 7.2% to $13.36 subsequent to a trading update for 2025. Olema Pharmaceuticals Inc (NASDAQ:OLMA) declined 5.5% to $26.37, extending its downward trend from a 3% loss on Tuesday.
Fresenius Medical Care AG (NYSE:FMS), a healthcare services company, dropped 4.8% to $21.79 in pre-market trading. Ambitions Enterprise Management Co LLC (NASDAQ:AHMA), despite surging 134% the previous day, retreated 4.3% to $11.81 in early trade.
Additional modest declines were recorded for NovaBay Pharmaceuticals Inc (NYSE:NBY), which fell 3.8% to $12.55 following a 3% dip on Tuesday, and SmartRent Inc (NYSE:SMRT), down 2.3% to $1.74.
These pre-market shifts underscore a volatile beginning to the trading session, with companies navigating a mix of regulatory challenges, capital raising effects, and earnings outlooks. Investors are closely monitoring these developments as they potentially set the tone for broader market performance throughout the day.