The U.S. stock market saw solid upward momentum on Monday, with the Dow Jones Industrial Average registering a gain exceeding 100 points. A variety of sectors contributed to the positive performance, propelled by fundamental announcements and strategic initiatives from multiple publicly traded companies.
Sarepta Therapeutics Inc. (NASDAQ: SRPT) experienced a sharp rise in its share price, climbing 9.8% to close at $23.20. This increase came in response to the release of topline three-year functional results from Part 1 patients in its EMBARK (Study SRP-9001-301) Phase 3 clinical trial of Elevidys (delandistrogene moxeparvovec-rokl). This gene therapy targets ambulatory individuals suffering from Duchenne muscular dystrophy. The data demonstrated statistically significant, clinically meaningful, and enduring efficacy across critical motor function assessments, including the North Star Ambulatory Assessment (NSAA), Time to Rise (TTR), and 10-meter walk/run (10MWR). These results were benchmarked against a pre-specified propensity-weighted untreated external control group, indicating durability of benefit three years after treatment initiation.
In the apparel segment, Lands’ End Inc. (NASDAQ: LE) saw its shares jump significantly by 38.8%, ending the session at $19.51. This sharp advancement followed the company’s announcement of a new joint venture with WHP Global with the objective of unlocking value from Lands’ End’s intellectual property holdings.
Other notable gainers included:
- Alpha Technology Group Ltd (NASDAQ: ATGL) with a rise of 26.8%, closing at $23.61.
- Rich Sparkle Holdings Ltd (NASDAQ: ANPA) ascending 22% to $64.66.
- TRX Gold Corp (NYSE: TRX) increased by 18% to $1.34. The precious metals sector benefits from heightened investor interest amid geopolitical concerns, including announcements of potential tariffs and government shutdown risks.
- Northern Dynasty Minerals Ltd (NYSE: NAK) rose 18%, finishing the day at $2.54. The rare-earths mining company’s stock appreciated alongside others in the sector, buoyed by the Trump administration’s acquisition of a 10% stake in USA Rare Earth, signaling governmental support for domestic resource development.
- GoldMining Inc (NYSE: GLDG) climbed 17.4%, settling at $2.22, riding the wave of investor demand for safe-haven assets.
- Greenwich Lifesciences Inc (NASDAQ: GLSI) surged 14.4% to $29.15 after FDA approval of the company’s first commercially manufactured GP2 lot for the FLAMINGO-01 Phase III clinical study, marking a regulatory milestone.
- USA Rare Earth Inc (NASDAQ: USAR) shares appreciated 14.3%, closing at $28.31, subsequent to the announcement of a non-binding letter of intent with the U.S. government seeking access to $1.6 billion in funding aimed at expediting the development of the domestic rare earth value chain.
- Zoom Communications Inc (NASDAQ: ZM) shares climbed 10.5% to $94.83 amid broad market strength.
- Almonty Industries Inc (NASDAQ: ALM) rose 10.2%, closing at $12.24, contributing to gains in industrial materials.
- Cloudflare Inc (NYSE: NET) advanced 10.2% to $191.11, benefiting from a rally in technology shares.
- CoreWeave Inc (NASDAQ: CRWV) increased by 9.5% to $101.88 following the announcement of an expanded collaboration with Nvidia Corporation (NASDAQ: NVDA). This partnership aims to accelerate the development of over 5 gigawatts of AI data centers by 2030, facilitating broader AI adoption worldwide.
The session’s activity reflects a mix of clinical progress, strategic corporate transactions, government involvement in critical sectors, and investor rotation into areas perceived as defensive or growth-oriented under current economic and geopolitical circumstances.
Investors showed particular interest in companies associated with emerging technologies and natural resources, influenced by regulatory approvals and government investments. The developments in the biotech sector with Sarepta Therapeutics underscore the impact that breakthrough clinical data can have on stock valuations, particularly when durable, clinically meaningful efficacy is demonstrated in serious conditions such as Duchenne muscular dystrophy.
The metals and rare earths sectors responded positively to announcements of governmental funding and stakes in domestic producers, reinforcing market sentiment about the strategic importance of these materials amid global supply chain considerations. Simultaneously, apparel stocks found impetus from innovative corporate arrangements designed to unlock previously underutilized asset value, exemplified by Lands’ End’s joint venture.
Technology companies including Zoom, Cloudflare, and CoreWeave gained traction in a broader technology rally, with CoreWeave’s expanded partnership with Nvidia spotlighting ongoing acceleration in AI infrastructure development.
Overall, Monday’s market performance was supported by a convergence of clinical data releases, strategic ventures, government funding initiatives, and a general appetite for both growth and defensive assets amid looming tariff and government shutdown uncertainties.