January 18, 2026
Finance

Significant Declines Mark Top Large-Cap Stock Performers for the Week of January 12-16, 2026

Stocks Including Regencell Bioscience and Trip.com Experience Notable Drops Amid Varied Market Factors

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Summary

During the week spanning January 12 to January 16, 2026, a group of large-cap stocks registered substantial declines in market value. Noteworthy among these were Regencell Bioscience Holdings, Trip.com Group, and technology firms such as Atlassian and Figma. Various causes contributed to these downward trends, including regulatory investigations and analyst adjustments to price targets.

Key Points

Regencell Bioscience experienced a 42.08% decline, the largest among large-cap stocks this week.
Trip.com Group's share price dropped 20.19% following an anti-monopoly investigation announcement by Chinese regulators.
Figma and HubSpot faced analyst price target reductions contributing to their notable stock declines.
Analysts maintained bullish outlooks on some stocks, like Atlassian, despite significant price decreases.

The week of January 12 through January 16, 2026, saw several large-cap stocks experience pronounced decreases in their share prices, underlining a period of market volatility for these corporations. A closer examination reveals distinct factors influencing investor sentiment and share performance across different sectors.

Regencell Bioscience Holdings Limited, listed on the NASDAQ under the ticker symbol RGC, stands out with a dramatic decline of 42.08% over the week. This substantial fall places the company at the forefront of the worst-performing large-cap equities within the defined period.

In the technology sector, Figma, Inc. (NYSE: FIG), a company known for its design collaboration tools, witnessed a 19.41% reduction in its stock value. This downturn followed a reassessment by Morgan Stanley analyst Elizabeth Porter, who opted to maintain an Equal-Weight rating but significantly lowered the price target for Figma's shares from $65 to $48. This adjustment likely influenced investor confidence and the resultant stock price drop.

Similarly, Atlassian Corporation, a provider of team collaboration and productivity software, experienced a 19.82% decrease in its share price within the week. Despite this setback, BTIG analyst Allan Verkhovski reaffirmed a Buy rating on Atlassian shares, maintaining a price target of $220, signaling a discrepancy between analyst optimism and market response during this timeframe.

Among the distinctly challenging cases is Trip.com Group Limited (NASDAQ: TCOM), which faced a 20.19% fall in its stock price. This decline coincided with the company's announcement of an investigation by China's State Administration for Market Regulation (SAMR) concerning possible anti-monopoly violations. The regulatory scrutiny appears to have triggered investor hesitancy, markedly impacting Trip.com Group's market valuation.

Additional large-cap stocks also exhibited notable negative performance throughout the week. DocuSign, Inc. (NASDAQ: DOCU) recorded a 6.42% decline, while HubSpot, Inc. (NYSE: HUBS) saw its stock price decrease by 16.56%, a movement partly driven by a Morgan Stanley revision reducing its price target from $640 to $577.

Intuit Inc. (NASDAQ: INTU) dropped 14.38% during the period. Despite this decline, the company made strides in expanding its physical presence, inaugurating the TurboTax SoHo flagship store at 463 Broadway. This flagship aims to offer nearly 600 expert offices and 20 retail stores nationwide. Concurrently, Intuit pledged a $100,000 contribution to New York City public schools, reflecting community investment amid market fluctuations.

Nutanix, Inc. (NASDAQ: NTNX), an enterprise cloud computing company, fell 13.19% during the week, with multiple analysts revising down their price forecasts for the stock. Guidewire Software, Inc. (NYSE: GWRE) and Summit Therapeutics Inc. (NASDAQ: SMMT) both experienced comparable declines of approximately 14.09%, adding to the trend of weakening stock values among technology and biotech sectors.

The collective movement of these large-cap stocks reflects a complex interplay of market sentiment, regulatory challenges, and analyst evaluations. Investors should note the diversity in causes, ranging from external regulatory investigations to internal reassessments by financial analysts, all contributing to the notable shifts observed.


Key Points

  • Regencell Bioscience Holdings Limited registered the steepest loss among large-cap stocks, falling over 42% during the week.
  • Regulatory investigations notably impacted Trip.com Group’s stock, with a 20.19% decline linked to an antitrust probe by China’s SAMR.
  • Analyst price target reductions contributed to share price drops for companies including Figma and HubSpot.
  • Despite setbacks, some analysts maintained optimistic ratings, as seen in BTIG’s Buy recommendation for Atlassian amidst share price decline.

Risks and Uncertainties

  • Ongoing regulatory scrutiny, such as the SAMR investigation into Trip.com, introduces significant uncertainty affecting stock valuations.
  • Analyst downgrades and lowered price targets may influence market perceptions and investor decisions, impacting stock prices negatively.
  • The broader market response to sector-specific challenges, including those in technology and biotech, may exacerbate volatility.
  • Corporate strategies and expansions, as demonstrated by Intuit, may not immediately translate into positive market performance, emphasizing operational risks amid fluctuating stock prices.
Risks
  • Regulatory investigations, such as China's SAMR probe into Trip.com, increase uncertainty around stock performance.
  • Adjustments to analyst price targets can strongly affect investor sentiment and share prices.
  • Sector-specific challenges contribute to increased volatility in technology and biotech stocks.
  • Corporate expansions may not immediately affect stock prices positively, reflecting operational and market risks.
Disclosure
Education only / not financial advice
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Ticker Sentiment
RGC - negative FIG - negative TEAM - negative TCOM - negative DOCU - negative
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